GLOSSARY
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IMPORTANT WORDS TO KNOW AND UNDERSTAND
A
Apheresis
The process of taking blood out of the body, removing certain parts of the blood, and then reintroducing the blood back into the body. This process is done in CAR T cell therapy to remove T cells before adding CARs to them. May also be called leukapheresis.
C
Certified treatment center
The place where you will receive Breyanzi® CAR T cell therapy. The healthcare team at these centers have been specially trained on how to administer and manage side effects of CAR T cell therapy.
Chimeric antigen receptor (CAR)
A specific receptor (or hook) that is added to a person’s T cells. The receptor can find and fight specific cells.
Copay
The out-of-pocket amount you pay for a healthcare service that is covered by your insurance plan, often after you’ve paid your deductible.
Cytokine
A type of protein that is made by certain immune and non-immune cells and has an effect on the immune system. Some cytokines stimulate the immune system and others slow it down.
Cytokine release syndrome (CRS)
A side effect of CAR T cell therapy that is potentially life-threatening and can lead to death. It is caused by a large, rapid release of cytokines, a type of protein, into the blood.
I
Immune system
The body’s natural defense against infection and diseases, including cancer.
Infusion
The method of putting fluids, including medicine, into the bloodstream using an intravenous (IV) method.
M
Manufacturing site
Where your T cells will be sent to become Breyanzi CAR T cells.
Median
The middle number in a group of numbers arranged from lowest to highest.
N
Neurologic toxicity (NT)
A side effect of CAR T cell therapy that is potentially life-threatening and can lead to death. It can cause damage to the nervous system.
R
Range
The smallest and largest numbers in a group of numbers.
Receptors
Structures on the surface of the cell that some substances can attach to.
Remission
When there are no signs or symptoms of cancer. It does not mean the cancer has been cured.
S
Systemic therapy
Treatment that travels through the bloodstream, reaching and affecting cells all over the body.
T
T cell
A type of cell found in the immune system that plays a role in fighting disease, including cancer.